Nucleic acid results in 5–15 minutes.
No thermal cycler.
RAA runs at a constant 37–42 °C, in lyophilised ready-to-use tubes, on a portable fluorescence analyzer — rapid molecular testing that goes where the sample is. For research use only.
Explore RAA technologyIsothermal. Lyophilised. Field-ready.
Recombinase-Aided Amplification (RAA) is a rapid isothermal nucleic acid amplification technology. A recombinase obtained from bacteria or fungi binds tightly to the primer DNA at ambient temperature, forming a recombinase–primer complex. When the primer locates its fully complementary sequence on the template, single-stranded DNA-binding protein helps open the double strand and DNA polymerase synthesises a new complementary strand. The product accumulates exponentially.
With a labelled fluorescent probe the reaction is read in real time; a result is typically available within 5–15 minutes. Two or more primer pairs in one tube allow multiplex detection of several targets in a single run. RAA is the platform behind every ZC Bioscience reagent, and all kits are developed and manufactured in-house.
- 01Simple operation
Molecular-level testing in a two-step workflow that does not require specialist staff.
- 02Fast
Results in 5–15 minutes — truly rapid testing.
- 03Accurate
High sensitivity and specificity; precise recognition of the target sequence.
- 04Portable
Compact instruments suited to harsh field conditions and on-site inspection.
- 05Isothermal
Runs at 30–42 °C; no thermal cycler or other expensive equipment required.
- 06Lyophilised
Freeze-dried pellets, ready to use, easy to ship, and free from freeze–thaw loss.
| Parameter | RAA ZC Bioscience | PCR | LAMP |
|---|---|---|---|
| Enzymes | Recombinase, single-stranded binding protein, strand-displacing DNA polymerase | Taq DNA polymerase | Strand-displacing DNA polymerase |
| Temperature | 37–39 °C, constant | High, thermal cycling | 60–65 °C |
| Time to result | 15 min | 1.5 h | 40 min |
| Primer pairs | 1 | 1 | 2 |
| Reagent format | Lyophilised pellet | Liquid | Liquid |
| Readout | Gel; real-time fluorescence; lateral-flow strip | Gel; real-time fluorescence | Visual turbidity |
| Limitation | — | Slow; thermal cycler required | Aerosol carry-over, false positives |
Every tube, every target, one platform.
Core amplification enzymes, portable instruments, rapid extraction chemistry and a ready-made food-safety detection series. Every reagent is supplied for research use only.
Request a quoteRAA core amplification kits
Pre-mixed, lyophilised reaction pellets for DNA or RNA targets. Choose gel, real-time fluorescence or lateral-flow readout. Primers 30–35 bp, probes 46–52 bp. Over 10⁷-fold amplification; 48 tests per kit, 50 μL reactions; store at −20 °C, 12 months.
- S001ZCRAA Basic Nucleic Acid Amplification Kit (DNA, gel readout) (RUO)48 tests · 37 °C · gelRequest a Quote
- S002ZCRAA Fluorescent Nucleic Acid Amplification Kit (DNA, real-time) (RUO)48 tests · 5–20 min · Genchek / qPCRRequest a Quote
- S003ZCRT-RAA Basic Nucleic Acid Amplification Kit (RNA, gel readout) (RUO)48 tests · 37 °C · gelRequest a Quote
- S004ZCRT-RAA Fluorescent Nucleic Acid Amplification Kit (RNA, real-time) (RUO)48 tests · 5–20 min · Genchek / qPCRRequest a Quote
- S005ZCRAA-nfo Nucleic Acid Amplification Kit (Lateral-Flow Strip, DNA) (RUO)48 tests · 39 °C · stripRequest a Quote
- S006ZCRT-RAA-nfo Nucleic Acid Amplification Kit (Lateral-Flow Strip, RNA) (RUO)48 tests · 42 °C · stripRequest a Quote
Genchek isothermal fluorescence analyzer
An integrated, portable analyzer for on-site and mobile testing. Built-in reagent mixing matched to RAA tubes, dual FAM & ROX channels, live amplification curves, automatic analysis and report export — all assays under one interface.
- GenchekGenchek Isothermal Fluorescence Analyzer8-well · portable · real-timeRequest a Quote
Rapid nucleic acid extraction kits
Purpose-built to deliver RAA-ready nucleic acid from tissue, blood, meat products, plant material, seeds, swabs and bacteria — no hazardous solvents, low cross-contamination risk. Store at room temperature, 12 months.
- ND01ZCRapid DNA Extraction Reagent (heat-lysis) (RUO)50 preps · 5 minRequest a Quote
- ND02ZCUniversal Rapid DNA Extraction Kit (Spin Column) (RUO)50 preps · 15 minRequest a Quote
- ND03ZCUniversal Rapid RNA Extraction Kit (Spin Column) (RUO)50 preps · 10 minRequest a Quote
- ND06ZCMagnetic-Bead DNA Extraction Pre-filled Plate (RUO)96 preps · 25 min · automatedRequest a Quote
Food safety molecular detection series
RAA fluorescent kits for meat-species authentication and foodborne pathogens. 24 tests per kit; 30–42 °C; result read from the amplification curve, no electrophoresis. Compatible with Genchek and standard real-time PCR instruments. Store at −20 °C, 6 months.
- A101ZCChicken-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A102ZCDuck-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A103ZCPork-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A104ZCBovine-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A105ZCOvine/Caprine (Sheep & Goat)-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A106ZCRat-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A107ZCHorse-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A108ZCMink-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A109ZCFox-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- A110ZCDonkey-Derived Ingredient Molecular Detection Kit (RAA, Fluorescent) (RUO)24 testsRequest a Quote
- B201ZCStaphylococcus aureus Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B202ZCSalmonella Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B203ZCPseudomonas aeruginosa Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B204ZCListeria monocytogenes Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B205ZCHaemolytic Streptococcus Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B206ZCVibrio parahaemolyticus Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
- B207ZCShigella Molecular Detection Kit (RAA, Fluorescent) (RUO)24 tests · 5–15 minRequest a Quote
Genchek fully automated isothermal nucleic acid detection system
Sample in, result out in 30 minutes. One benchtop system performs pipetting, lysis, nucleic acid purification, isothermal amplification, fluorescence detection, analysis and reporting — hands-off after loading.
Request a quote- GenchekGenchek Fully Automated Isothermal Nucleic Acid Detection Systemextraction + amplification · 30 minRequest a Quote
Animal-derived ingredient detection
As price gaps between meats widen, species substitution and adulteration are increasingly common. RAA species kits detect species-specific genes with no cross-reaction between species, identifying meat origin at the molecular level in animal tissue, blood, foods, processed meat and feed.
- Chicken A101ZC
- Pork A103ZC
- Duck A102ZC
- Beef A104ZC
- Sheep / goat A105ZC
- Rat A106ZC
- Horse A107ZC
- Mink A108ZC
- Fox A109ZC
- Donkey A110ZC
Users · food & drug regulators · customs and border inspection · livestock authorities · agricultural research institutes · food, supplement and feed manufacturers · third-party laboratories
Discuss this solution
Foodborne pathogen detection
Pathogenic bacteria account for an estimated 40–50 % of reported foodborne-illness cases in China each year. RAA pathogen kits combine multi-channel detection, short run times and high sensitivity — raising throughput, moving food-safety warnings earlier and cutting labour cost, across foods, beverages, cosmetics and seafood.
- Staphylococcus aureus B201ZC
- Salmonella B202ZC
- Pseudomonas aeruginosa B203ZC
- Listeria monocytogenes B204ZC
- Haemolytic Streptococcus B205ZC
- Vibrio parahaemolyticus B206ZC
- Shigella B207ZC
- E. coli O157:H7 Enquire
- Vibrio cholerae Enquire
Users · food & drug regulators · customs and border inspection · public-health laboratories · food and cosmetics manufacturers · third-party laboratories
Discuss this solution
Transgenic ingredient detection
GM crops carry genes introduced from other organisms to alter traits, nutrition or quality. Regulators worldwide require labelling and control to protect consumers' right to know. RAA-based GMO kits specifically detect exogenous elements in crops, identifying GM material at the molecular level.
- Bt Gene
- bar Gene
- hpt Gene
- CaMV 35S Promoter
- FMV 35S Promoter
- nos Terminator
Users · food & drug regulators · customs and border inspection · agricultural research institutes · food, supplement and feed manufacturers · third-party laboratories
Discuss this solutionFrom your first run to your own assay.
Our R&D team supports every product with consultation, documentation, training and long-term technical follow-up — and develops custom RAA assays when the target you need is not on the list.
Technical service
Expert technical support: our R&D team answers every product question with patient explanation and demonstration. We provide consultation, technical documentation, training and after-sales support for reagents and instruments alike.
- Application consultation
- Instructions for use & technical files
- Operator training
After-sales support
Good after-sales service earns trust. If a problem arises, our engineers respond promptly and resolve issues remotely by e-mail or phone; long-term technical documentation and support are part of every supply agreement.
- Remote troubleshooting
- Instrument service coordination
- Mon–Fri 9:00–18:00 (UTC+8)
Custom assay development
RAA is a versatile, portable rapid-testing platform that can replace LAMP or PCR in many workflows. Tell us your target sequence and sample type — we design primers and probes, lyophilise the mix and deliver a ready-to-run kit. OEM supply available.
- Target-specific RAA kits
- OEM / private-label reagents
- Co-development agreements
Built around one amplification chemistry.
Hangzhou ZC Bio-Sci & Tech Co., Ltd. ("ZC Bioscience") is an R&D-driven biotechnology company based in Hangzhou, China. We develop and apply Recombinase-Aided Amplification and supply RAA-based reagents, extraction kits and portable fluorescence instruments for rapid molecular testing.
Food safety first, then everywhere a sample needs an answer.
Since September 2016 the company has accelerated product development for RAA-based rapid food-safety testing, launching in turn the animal-species molecular detection series, the foodborne pathogen molecular detection series and the GMO ingredient molecular detection series. Other application areas include environmental monitoring, aquaculture pathogen detection and animal disease detection.
Co-developing detection kits with partners.
ZC Bioscience has signed strategic cooperation agreements with government institutions and research organisations across several fields to co-develop RAA-based detection kits. We remain committed to advancing RAA technology and delivering rapid-testing products and services that are fast, accurate and easy to use. Selected for the Hangzhou Binjiang District "5050 Talent Program" and a key enterprise cultivated by the district.
Notes from the bench and the floor.
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Literature | Rapid nucleic acid amplification by Recombinase-Aided Amplification
In-vitro rapid amplification lets trace amounts of nucleic acid be multiplied efficiently outside the cell, and has been widely adopted in molecular biology. RAA develops that principle into an isothermal method — this note collects the primary literature behind the platform.
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Explainer | Recombinase-aided rapid nucleic acid amplification
RAA replaces the thermal-cycling denaturation of conventional PCR with a recombinase, single-stranded binding protein and DNA polymerase, achieving rapid amplification at a constant 37 °C. Over the past decade several isothermal methods have developed rapidly — including SDA, TMA, HDA, LAMP and RAA.
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Highlights | RAA technology debuts at the Food Microbiology Detection & Control Exchange
On 20–22 July 2017 the 7th Food Microbiology Detection and Control Technology Exchange was held in Shanghai, co-organised by the Agro-product Safety Research Center of the Chinese Academy of Inspection and Quarantine, the Analytical Microbiology Committee of the Chinese Society for Microbiology and Foodmate. Over 30 exhibitors and 300+ laboratory professionals attended.
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Forum | 7th Food Microbiology Detection & Control Technology Exchange, 19–22 July
Foodborne disease caused by pathogenic microorganisms is the number-one food-safety issue. Controlling contamination, strengthening laboratory capability and applying advanced microbial detection and control technology in production have become focal concerns for regulators and food companies alike.
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ZC Bioscience at the 10th China International Food Safety & Quality Conference (CBIFS 2017)
The annual CBIFS food-safety technology forum was held on 7–8 April 2017 at the Hangzhou International Expo Center. ZC Bioscience, a newcomer to food-safety testing, made its debut at the conference with its portable rapid-testing case, RAA detection kits and the Genchek fluorescence analyzer.
Tell us your target.
Send us the target, sample type and volume you have in mind and we will reply with a quotation, technical files and lead time. Reagents are supplied for research use only.
- AddressTianhe Hi-Tech Park, Bldg 5, 688 Bin'an Rd, Binjiang District, Hangzhou 310052, China
- E-mailzcsw2017@163.com
- Phone+86 571 8861 9668
- HoursMon–Fri 9:00–18:00 (UTC+8)
- CompanyHangzhou ZC Bio-Sci & Tech Co., Ltd.